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MK-0812 (Succinate)
$180 – $1,860
Products Details
Product Description
– MK-0812 Succinate is a potent and selective CCR2 antagonist with high affinity at CCR2.
Web ID
– HY-50669A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C28H40F3N3O7
References
– [1]Min SH, et al. Pharmacological targeting reveals distinct roles for CXCR2/CXCR1 and CCR2 in a mouse model of arthritis.Biochem Biophys Res Commun. 2010 Jan 1;391(1):1080-6.|[2]Wisniewski T, et al. Assessment of chemokine receptor function on monocytes in whole blood: In vitro and ex vivo evaluations of a CCR2 antagonist.J Immunol Methods. 2010 Jan 31;352(1-2):101-10.
CAS Number
– 851916-42-2
Molecular Weight
– 587.63
Compound Purity
– 99.94
SMILES
– O=C([C@]1(C(C)C)C[C@H](N[C@H]2CCOC[C@H]2OC)CC1)N3CCC(N=CC(C(F)(F)F)=C4)=C4C3.O=C(O)CCC(O)=O
Clinical Information
– Phase 2
Research Area
– Inflammation/Immunology; Endocrinology
Solubility
– DMSO : ≥ 32 mg/mL
Target
– CCR
Isoform
– CCR2
Pathway
– GPCR/G Protein;Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
