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Methylene blue (trihydrate)
$30 – $60
Products Details
Product Description
– Methylene blue trihydrate (C.I. Basic Blue 9 trihydrate) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue trihydrate is a vasopressor and is often used as a dye in several medical procedures. Methylene blue trihydrate has antinociception, antimalarial, antidepressant and anxiolytic activity effects. Methylene Blue trihydrate has the potential for methemoglobinemias, neurodegenerative disorders and ifosfamide-induced encephalopathytreatment[1][2][3].
Web ID
– HY-B1359
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C16H24ClN3O3S
References
– [1]Delport A, et al. Methylene blue and its analogues as antidepressant compounds. Metab Brain Dis. 2017 Oct;32(5):1357-1382.|[2]Masaki E, et al. Methylene blue, a soluble guanylyl cyclase inhibitor, reduces the sevoflurane minimum alveolar anesthetic concentration and decreases the brain cyclic guanosine monophosphate content in rats. Anesth Analg. 1999 Aug;89(2):484-9.|[3]McCartney SL, et al. Intraoperative vasoplegia: methylene blue to the rescue! Curr Opin Anaesthesiol. 2018 Feb;31(1):43-49.
CAS Number
– 7220-79-3
Molecular Weight
– 373.90
Compound Purity
– 98.0
SMILES
– CN(C1=CC(SC2=C/C(C=CC2=N3)=[N+](C)C)=C3C=C1)C.[3 H2O].[Cl-]
Clinical Information
– Launched
Research Area
– Cancer; Infection; Neurological Disease
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– Guanylate Cyclase;Monoamine Oxidase;NO Synthase;Parasite
Isoform
– Plasmodium
Pathway
– Anti-infection;GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
