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Mecamylamine
Products Details
Product Description
– Mecamylamine is an orally active, nonselective, noncompetitive nAChR antagonist. Mecamylamine is also a ganglionic blocker. Mecamylamine can across the blood-brain barrier. Mecamylamine can be used in the research of neuropsychiatric disorders, hypertension, antidepressant area[1][2][5].
Web ID
– HY-B1395A
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C11H21N
Citations
– Nat Commun. 2023 Apr 17;14(1):2182.|bioRxiv. 2023 Jul 6.
References
– [1]Omar Hernández-González, et al. Mechanisms of stimulatory effects of mecamylamine on the dorsal raphe neurons. Brain Res Bull. 2020 Nov;164:289-298. |[2]C P Robinson, et al. The influence of mecamylamine on contractions induced by different agonists and on the role of calcium ions in the isolated rabbit aorta. J Pharmacol Exp Ther. 1976 Apr;197(1):57-65. |[3]Mahadevappa P Badanavalu, et al. Nicotine is neuroprotective to neonatal neurons of sympathetic ganglion in rat. Auton Neurosci. 2019 Jan;216:25-32. |[4]Katsuji Kiuchi, et al. Mecamylamine suppresses Basal and nicotine-stimulated choroidal neovascularization. Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1705-11. |[5]Rabenstein RL, et al. The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not beta2- or alpha7-nicotinic acetylcholine receptor subunit knockout mice. Psychopharmacology (Berl). 2006 Dec;189(3):395-401.
CAS Number
– 60-40-2
Molecular Weight
– 167.29
SMILES
– CC1(C)C(NC)(C)C2CCC1C2
Clinical Information
– Launched
Research Area
– Neurological Disease; Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Histamine Receptor;nAChR
Pathway
– GPCR/G Protein;Immunology/Inflammation;Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
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