Products Details

Product Description

– MC-VC-PAB-MMAD is a agent-linker conjugate for ADC with potent antitumor activity by using MMAD (a potent tubulin inhibitor), linked via the cleavable ADC linker MC-VC-PAB[1].

Web ID

– HY-136316

Shipping

– Room temperature

Applications

– Cancer-programmed cell death

Molecular Formula

– C71H105N11O14S

References

– [1]Chudasama V, et al. Recent advances in the construction of antibody-drug conjugates. Nat Chem. 2016 Feb;8(2):114-9.

Molecular Weight

– 1368.72

SMILES

– O=C(C[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(COC(N(C)[C@@H](C(C)C)C(N[C@H](C(N(C)[C@H]([C@@H](CC(N2[C@H]([C@@H]([C@H](C(N[C@@H](CC3=CC=CC=C3)C4=NC=CS4)=O)C)OC)CCC2)=O)OC)[C@@H](C)CC)=O)C(C)C)=O)=O)C=C1)=O)=O)CCCCCN5C(C=CC5=O)=O

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– 10 mM in DMSO

Target

– Drug-Linker Conjugates for ADC;Microtubule/Tubulin

Isoform

– Auristatin

Pathway

– Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage;Cytoskeleton

Product type

– ADC Related

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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