Download Files:
LY294002
Price range: 54 CAD through 206 CAD
Products Details
Product Description
– LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM). LY294002 is also an inhibitor of DNA-PK (IC50=1.4 μM) and an inhibitor of CK2 (IC50=98 nM). LY294002 activates apoptosis and autophagy.
Web ID
– T2008
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C19H17NO3
Citations
– 1. Jiang Y, Zhao X, Chen J, et al.PM2. 5 induces cardiac malformations via PI3K/akt2/mTORC1 signaling pathway in zebrafish larvae.Environmental Pollution.2023: 121306.
2. Ye L, Huang Y, Liu X, et al.Apelin/APJ system protects placental trophoblasts from hypoxia-induced oxidative stress through activating PI3K/Akt signaling pathway in preeclampsia.Free Radical Biology and Medicine.2023
3. Zou X, Zeng M, Zheng Y, et al.Comparative Study of Hydroxytyrosol Acetate and Hydroxytyrosol in Activating Phase II Enzymes.Antioxidants.2023, 12(10): 1834.
4. Gao J, Wang N, Zong F, et al.TIPE2 regulates the response of BV2 cells to lipopolysaccharide by the crosstalk between PI3K/AKT signaling and microglia M1/M2 polarization.International Immunopharmacology.2023, 120: 110389.
5. Li W Y, Shi T S, Huang J, et al.Activation of the mTORC1 signaling cascade in the hippocampus and medial prefrontal cortex is required for the antidepressant actions of vortioxetine in mice.International Journal of Neuropsychopharmacology.2023: pyad017.
6. Shan X, Jiang R, Gou D, et al.Identification of a diketopiperazine‐based O‐GlcNAc transferase inhibitor sensitizing hepatocellular carcinoma to CDK9 inhibition.The FEBS Journal.2023
7. Tang P, Tang Y, Liu Y, et al.Quercetin-3-O-α-L-arabinopyranosyl-(1→ 2)-β-D-glucopyra-noside Isolated from Eucommia ulmoides Oliver Leaf Relieves Insulin Resistance in HepG2 cells via the IRS-1/PI3K/Akt/GSK-3β pathway.Biological and Pharmaceutical Bulletin.2022: b22-00597.
8. Zhang Z D, Li H X, Gan H, et al. RNF115 Inhibits the Post-ER Trafficking of TLRs and TLRs-Mediated Immune Responses by Catalyzing K11-Linked Ubiquitination of RAB1A and RAB13. Advanced Science. 2022: 2105391
9. Chen Y, Sun Y, Zhao W, et al. Elevated SRC3 expression predicts pemetrexed resistance in lung adenocarcinoma. Biomedicine & Pharmacotherapy. 2020, 125: 109958.
10. Gu L, Ye P, Li H, et al. Lunasin attenuates oxidant‐induced endothelial injury and inhibits atherosclerotic plaque progression in ApoE −/− mice by up‐regulating heme oxygenase‐1 via PI3K/Akt/Nrf2/ARE pathway. The FASEB Journal. 2019, 33(4): 4836-4850
References
– Mao Y, et al. Regulation of cell apoptosis and proliferation in pancreatic cancer through PI3K/Akt pathway via Polo-like kinase Oncol Rep. 2016 Jul;36(1):49-56.
CAS Number
– 154447-36-6
Molecular Weight
– C19H17NO3
Compound Purity
– 0.9996
SMILES
– O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCOCC1
Target
– Androgen Receptor
Pathway
– Metabolism|||PI3K/Akt/mTOR signaling|||DNA Damage/DNA Repair|||Autophagy|||Apoptosis|||Stem Cells
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
Related Products
1000 in stock
1000 in stock
