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Product Description
– LY 163443 is a selective antagonist of leukotrienes D4 (LTD4) and E4 (LTE4). LY 163443 can antagonize LTD4-induced contractions of guinea pig ileum, trachea, and lung parenchyma. LY 163443 also inhibits tracheal contractions to LTE4[1][2].
Web ID
– HY-113758
Shipping
– Room temperature
Molecular Formula
– C20H22N4O3
References
– [1]Fleisch JH, et, al. Evaluation of LY163443, 1-[2-hydroxy-3-propyl-4-([4- (1H-tetrazol-5-ylmethyl)phenoxy]methyl) phenyl]ethanone, as a pharmacologic antagonist of leukotrienes D4 and E4. Naunyn Schmiedebergs Arch Pharmacol. 1986 May;333(1):70-7. |[2]Bitterman H, et, al. Use of a novel peptide leukotriene receptor antagonist, Ly-163443, in splanchnic artery occlusion shock. Prostaglandins Leukot Essent Fatty Acids. 1988 May;32(2):63-70.
CAS Number
– 97581-70-9
Molecular Weight
– 366.41
SMILES
– CC(C1=CC=C(C(CCC)=C1O)COC2=CC=C(C=C2)CC3=NN=NN3)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Leukotriene Receptor
Pathway
– GPCR/G Protein
Product type
– Reference compound
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