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Products Details
Product Description
– LSD1-IN-20 (compound 1) is a potent dual non-covalent LSD1/G9a inhibitor, with Ki values of 0.44 and 0.68 μM, respectively. LSD1-IN-20 shows antiproliferative activity in THP-1 leukemia cells and MDA-MB-231 breast cancer cells, with IC50 (72 h) of 0.51 and 1.60 μM, respectively[1].
Web ID
– HY-146285
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C27H38N6O2
References
– [1]Menna M, et al. Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models. Eur J Med Chem. 2022 Jul 5;237:114410.
CAS Number
– 1239589-91-3
Molecular Weight
– 478.63
SMILES
– COC1=CC2=C(C(NC3CCN(CC3)CC4=CC=CC=C4)=NC(NCCCN(C)C)=N2)C=C1OC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Histone Demethylase;Histone Methyltransferase
Isoform
– KDM1/LSD1
Pathway
– Epigenetics
Product type
– Reference compound
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