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Loteprednol Etabonate-d3
Products Details
Product Description
– Loteprednol Etabonate-d3 is the deuterium labeled Loteprednol Etabonate. Loteprednol etabonate (LE) is an orally active “soft” steroid belonging to a unique class of glucocorticoids. Loteprednol etabonate (LE) exhibits anti-inflammatory activity and has been used in optometry and ophthalmology[1][2][3].
Web ID
– HY-17358S1
Shipping
– Room temperature
Molecular Formula
– C24H28D3ClO7
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Noble S, Goa KL. Loteprednol etabonate: clinical potential in the management of ocular inflammation. BioDrugs. 1998 Oct;10(4):329-39.|[3]Szelenyi I, Hochhaus G, Heer S et al. Loteprednol etabonate: a soft steroid for the treatment of allergic diseases of the airways. Drugs Today (Barc). 2000 May;36(5):313-20.|[4]Howes JF. Loteprednol etabonate: a review of ophthalmic clinical studies. Pharmazie. 2000 Mar;55(3):178-83.|[5]Pavesio CE, Decory HH. Treatment of ocular inflammatory conditions with loteprednol etabonate. Br J Ophthalmol. 2008 Apr;92(4):455-9.|[6]Comstock TL, Decory HH. Advances in corticosteroid therapy for ocular inflammation: loteprednol etabonate. Int J Inflam. 2012;2012:789623.
Molecular Weight
– 469.97
SMILES
– O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])CC[C@]4(OC(OCC([2H])([2H])[2H])=O)C(OCCl)=O)=C1
Clinical Information
– No Development Reported
Research Area
– Infection; Endocrinology; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Antibiotic;Bacterial;Glucocorticoid Receptor;Isotope-Labeled Compounds
Pathway
– Anti-infection;Immunology/Inflammation;Others;Vitamin D Related/Nuclear Receptor
Product type
– Isotope-Labeled Compounds
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