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Products Details
Product Description
– Lenalidomide (sodium), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (sodium) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (sodium) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells[1][2].
Web ID
– HY-A0003C
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C13H13N3NaO3
References
– [1]Venumadhav Kotla, et, al. Mechanism of action of lenalidomide in hematological malignancies. J Hematol Oncol. 2009, 2, 36.|[2]Jan Krönke, et, al. Lenalidomide induces degradation of IKZF1 and IKZF3. Oncoimmunology. 2014, 3,7.
Molecular Weight
– 282.25
SMILES
– O=C1C2=CC=CC(N)=C2CN1C(C(N3)=O)CCC3=O.[Na]
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Ligands for E3 Ligase
Pathway
– PROTAC
Product type
– Reference compound
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