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Product Description
– Lenalidomide (sodium), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (sodium) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (sodium) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells[1][2].
Web ID
– HY-A0003C
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C13H13N3NaO3
References
– [1]Venumadhav Kotla, et, al. Mechanism of action of lenalidomide in hematological malignancies. J Hematol Oncol. 2009, 2, 36.|[2]Jan Krönke, et, al. Lenalidomide induces degradation of IKZF1 and IKZF3. Oncoimmunology. 2014, 3,7.
Molecular Weight
– 282.25
SMILES
– O=C1C2=CC=CC(N)=C2CN1C(C(N3)=O)CCC3=O.[Na]
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Ligands for E3 Ligase
Pathway
– PROTAC
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
