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L-Ascorbic acid (sodium salt)
$50 – $60
Products Details
Product Description
– L-Ascorbic acid sodium salt (Sodium ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid sodium salt selectively inhibits Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid sodium salt is also a collagen deposition enhancer and an elastogenesis inhibitor[1][2][3].
Web ID
– HY-B0166A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture and light)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C6H7NaO6
Citations
– Environ Toxicol. 2021 Apr;36(4):520-529.|FASEB J. 2020 Sep;34(9):11474-11487.|J Afr Ass Physiol Sci. 7(1): 30-37, July 2019.|Mil Med Res. 2020 Nov 1;7(1):52.|Antioxid Redox Signal. 2020 Dec 10;33(17):1191-1208.|Biomed Pharmacother. September 2022, 113558.|Bioorg Chem. 2021, 105177.|Biosci Rep. 2019 May 21;39(5):BSR20182137.|Cell Biol Toxicol. 2021 Jul 20.|Cell Cycle. 2022 Nov 12;1-18.|Cytotechnology. 02 October 2021.|Drug Chem Toxicol. 2023 Feb 23;1-9.|Eur J Med Chem. 2022 Jan 28;231:114151.|Fitoterapia. 2021 Jun 30;104984.|Food Funct. 2022 May 10;13(9):5089-5101.|Free Radic Biol Med. 2020 Feb 1;147:220-230.|Int J Biol Macromol. 2023 Nov 17:127779.|J Biol Chem. 2023 Nov 15:105462.|J Cell Mol Med. 2020 Apr;24(7):4212-4222.|J Nat Prod. 2022 Jul 7.|J Neurosci Res. 2019 Dec;97(12):1689-1705. |J Pharmacol Toxicol Methods. Nov-Dec 2020;106:106913.|J Sex Med. 2018 Feb;15(2):136-147. |Mol Med Rep. 2019 Dec; 20(6): 4933–4942.|Nat Immunol. 2022 Dec 21.|Nigerian Journal of Scientific Research. 18 (3): 2019.|Oxid Med Cell Longev. 2022 Jan 27;2022:7502632.|Redox Biol. 2022 Aug;54:102392.|Research Square Print. 2022 Aug.|Sci China Life Sci. 2018 Oct;61(10):1151-1167.
References
– [1]Hinek A, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82.|[2]Morimura K, et al. Lack of urinary bladder carcinogenicity of sodium L-ascorbate in human c-Ha-ras proto-oncogene transgenic rats. Toxicol Pathol. 2005;33(7):764-7.|[3]Takagi H, et al. Limited tumor-initiating activity of phenylethyl isothiocyanate by promotion with sodium L-ascorbate in a rat two-stage urinary bladder carcinogenesis model. Cancer Lett. 2005 Mar 10;219(2):147-53.|[4]Yang X, et al. Mouse melanoma cell line B16F10-derived conditioned medium inhibits sodium L-ascorbate-induced B16F10 cell apoptosis. Nan Fang Yi Ke Da Xue Xue Bao. 2012 Feb;32(2):146-50.|[5]Aleksander Hinek, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82.|[6]Michael T Nelson, et al. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J Neurosci. 2007 Nov 14;27(46):12577-83.
CAS Number
– 134-03-2
Molecular Weight
– 198.11
Compound Purity
– 99.97
SMILES
– O[C@@H](CO)[C@]1([H])C(O[Na])=C(O)C(O1)=O
Clinical Information
– Launched
Research Area
– Cancer
Solubility
– DMSO : 1 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)
Target
– Apoptosis;Calcium Channel;Endogenous Metabolite;Reactive Oxygen Species
Isoform
– Human Endogenous Metabolite;Microbial Metabolite;T-type calcium channel
Pathway
– Apoptosis;Immunology/Inflammation;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling;NF-κB
Product type
– Natural Products
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
