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K-Ras ligand-Linker Conjugate 5
$900 – $990
Products Details
Product Description
– K-Ras ligand-Linker Conjugate 5 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 5 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1].
Web ID
– HY-130823
Storage Temperature
– -20°C (Powder, stored under nitrogen)
Shipping
– Blue Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C42H59N7O8
References
– [1]CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2.
CAS Number
– 2378261-85-7
Molecular Weight
– 789.96
Compound Purity
– 96.96
SMILES
– O=C(N1[C@@H](CC#N)CN(C2=C3C(CN(C4=C5C=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)C[C@H](OCCOCCOCCOCCO)C6)=N2)CC1)OC(C)(C)C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Target Protein Ligand-Linker Conjugates
Pathway
– PROTAC
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
