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K-Ras ligand-Linker Conjugate 4
120 CAD
Only 1000 item(s) left in stock.
Products Details
Product Description
– K-Ras ligand-Linker Conjugate 4 is a chemical compound combining a K-Ras recruiting ligand with a PROTAC linker, responsible for recruiting E3 ligases such as VHL, CRBN, MDM2, and IAP. It has the potential to be used in synthesizing PROTAC K-Ras Degrader-1, which shows a degradation efficacy of ≥70% in SW1573 cells[1].
Web ID
– T18057
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C35H51N7O8
References
– CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2.
CAS Number
– 2378261-83-5
Molecular Weight
– C35H51N7O8
SMILES
– O(C[C@@H]1C[C@@H](OCCOCCOCCOCCO)CN1C)C2=NC(=C3C(=N2)CNCC3)N4C[C@H](CC#N)N(C(OCC5=CC=CC=C5)=O)CC4
Target
– Others
Pathway
– Others
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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