K-Ras ligand-Linker Conjugate 2

Products Details

Product Description

– K-Ras ligand-Linker Conjugate 2 incorporates a ligand for K-Ras, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 2 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1].

Web ID

– HY-129776

Shipping

– Room temperature

Applications

– Cancer-programmed cell death

Molecular Formula

– C45H58N8O7

References

– [1]CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2.

CAS Number

– 2741300-61-6

Molecular Weight

– 822.99

SMILES

– NCCOCCOCCOCCO[C@H]1CN(C)[C@H](COC2=NC3=C(CCN(C4=CC=CC5=C4C=CC=C5)C3)C(N6CCN(C(OCC7=CC=CC=C7)=O)[C@@H](CC#N)C6)=N2)C1

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– 10 mM in DMSO

Target

– Target Protein Ligand-Linker Conjugates

Pathway

– PROTAC

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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