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Products Details
Product Description
– K-Ras ligand-Linker Conjugate 1 incorporates a ligand for K-Ras, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 1 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1].
Web ID
– HY-129775
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C43H54N8O9
References
– [1]CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2.
CAS Number
– 2749492-84-8
Molecular Weight
– 826.94
SMILES
– O=C(N1CCOCCOCCOCCO[C@@H]2C[C@@H](COC3=NC4=C(CCNC4)C(N5CCN(C(OCC6=CC=CC=C6)=O)[C@@H](CC#N)C5)=N3)N(C)C2)C7=C(C=CC=C7)C1=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Target Protein Ligand-Linker Conjugates
Pathway
– PROTAC
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
