K-975

SKU HY-138565-10 mg Category Tags , ,

$200$1,250

Products Details

Product Description

– K-975 is a potent, selective and orally active TEAD inhibitor, with a strong inhibitory effect against protein-protein interactions between YAP1/TAZ and TEAD. K-975 covalently binds to Cys359 located in the palmitate-binding pocket of TEAD via an acrylamide structure. K-975 exhibits antitumor activity on malignant pleural mesothelioma[1].

Web ID

– HY-138565

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– Cancer-programmed cell death

Molecular Formula

– C16H14ClNO2

References

– [1]Kaneda A, et, al. The novel potent TEAD inhibitor, K-975, inhibits YAP1/TAZ-TEAD protein-protein interactions and exerts an anti-tumor effect on malignant pleural mesothelioma. Am J Cancer Res. 2020 Dec 1;10(12):4399-4415.

CAS Number

– 2563855-03-6

Molecular Weight

– 287.74

Compound Purity

– 99.27

SMILES

– C=CC(NC1=CC=C(C)C(OC2=CC=C(Cl)C=C2)=C1)=O

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– DMSO : 220 mg/mL (ultrasonic)

Target

– YAP

Pathway

– Stem Cell/Wnt

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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