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Ionomycin
$50 – $380
Products Details
Product Description
– Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC)[1][2][3].
Web ID
– HY-13434
Storage Temperature
– Solution, -20°C, 2 years
Shipping
– Blue Ice
Applications
– Cancer-Kinase/protease
Molecular Formula
– C41H72O9
Citations
– ACS Infect Dis. 2023 Mar 14.|Acta Pharmacol Sin. 2022 Sep 23.|Adv Sci (Weinh). 2023 Jan 15;e2203869.|Aging. 2019 Aug 19;11(16):6490-6502.|Aging. 2021 Jun 2;13(11):15638-15658.|Aging. 2021 Mar 24;13(7):10312-10325.|Biomed Pharmacother. 2022 Jan 17;147:112644.|Cancer Cell. 2023 Jun 12;41(6):1170-1185.e12.|Cancer Commun (Lond). 2022 Jan 3.|Cancer Res. 2023 Jan 12;CAN-22-2405.|Cell Calcium. 2022 Jun;104:102571.|Cell Death Dis. 2021 Apr 1;12(4):336.|Cell Mol Immunol. 2022 Feb 22.|Cell Rep. 2021 Jul 20;36(3):109404.|Eur J Pharmacol. 2021 Nov 9;174623.|Evid-Based Compl Alt. 2021 Jan 7.|Front Immunol. 05 August 2022.|Int Immunopharmacol. 2023 Sep 1;124(Pt A):110865.|Int J Biol Macromol. 2023 Jun 13;125373.|Int J Mol Sci. 2023 Aug 8, 24(16), 12557.|J Ethnopharmacol. 2022 Dec 8;303:116031.|J Immunol. 2021 Mar 1;206(5):963-977.|J Neuroimmunol. 2020 Aug 15;345:577286.|Microorganisms. 2023 Feb 27.|Mol Cell. 2022 May 5;S1097-2765(22)00327-6.|Nat Commun. 2023 Feb 23;14(1):1020.|Preprints. 2023 Mar 6.|Proc Natl Acad Sci U S A. 2022 Feb 22;119(8):e2114851119.|Protein Cell. 2021 Oct 22;1-21.|Redox Biol. 2023 Nov 10, 102959.|Reprod Fert Develop. 33(2) 108-108.|Research Square Preprint. 2023 Aug 11.|Research Square Print. 2022 Jun.|Sci Signal. 2023 Feb 28;16(774):eadd0645.|Sci Total Environ. 2021, 146523.|Sci Transl Med. 2020 Nov 25;12(571):eaaz6667.|Theranostics. 2023 May 8;13(9):2879-2895.|Vaccines. 2023 May 25, 11(6), 1026.|Int Immunopharmacol. 2023 Nov 16:126:111212.|OncoImmunology. 2023 Oct 12;12(1):2268257.
References
– [1]Gil-Parrado S, et al. Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members. J Biol Chem. 2002 Jul 26;277(30):27217-26.|[2]Liu C,et al. Characterization of ionomycin as a calcium ionophore. J Biol Chem. 1978 Sep 10;253(17):5892-4.|[3]Chatila T, et al. Mechanisms of T cell activation by the calcium ionophore ionomycin. J Immunol. 1989 Aug 15;143(4):1283-9.|[4]Stoeck A, et al A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44. Biochem J. 2006 Feb 1;393(Pt 3):609-18.|[5]Junsuke Uwada, et al. Store-operated calcium entry (SOCE) contributes to phosphorylation of p38 MAPK and suppression of TNF-α signalling in the intestinal epithelial cells. Cell Signal. 2019 Nov;63:109358.
CAS Number
– 56092-81-0
Molecular Weight
– 709.01
Compound Purity
– 99.0
SMILES
– O=C(O)CC[C@@H](C)C[C@H](C)C[C@H](C)C(/C=C(O)/[C@H](C)C[C@H](C)C/C=C/[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]1CC[C@]([C@@H]2O[C@](C)([C@H](O)C)CC2)(C)O1)=O
Clinical Information
– No Development Reported
Research Area
– Cancer; Infection
Solubility
– DMSO : 100 mg/mL (ultrasonic)|Ethanol : 100 mg/mL (ultrasonic)
Target
– Antibiotic;Apoptosis;Bacterial;Calcium Channel;PKC
Pathway
– Anti-infection;Apoptosis;Epigenetics;Membrane Transporter/Ion Channel;Neuronal Signaling;TGF-beta/Smad
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
