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Indoximod
$60
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Products Details
Product Description
– Indoximod (1-Methyl-D-tryptophan) is an orally active indoleamine 2,3-dioxygenase (IDO) pathway inhibitor. Indoximod acts as a Trp mimetic in regulating mTOR. Indoximod is an immunometabolic adjuvant used for the research of cancer[1][2].
Web ID
– HY-16724
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C12H14N2O2
References
– [1]Metz R, et al. IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan. Oncoimmunology. 2012;1(9):1460-1468. |[2]Hou DY, et al. Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophancorrelates with antitumor responses. Cancer Res. 2007 Jan 15;67(2):792-801.
CAS Number
– 110117-83-4
Molecular Weight
– 218.25
Compound Purity
– 99.39
SMILES
– N[C@H](CC1=CN(C)C2=CC=CC=C12)C(O)=O
Clinical Information
– Phase 2
Research Area
– Cancer
Solubility
– DMSO : 0.55 mg/mL (ultrasonic;warming)|H2O : 5 mg/mL (ultrasonic;adjust pH to 2 with HCl)
Target
– Indoleamine 2,3-Dioxygenase (IDO)
Isoform
– IDO
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
