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Indisulam
Price range: 48 CAD through 530 CAD
Products Details
Product Description
– Indisulam (E 7070) is a carbonic anhydrase inhibitor and antitumor CDK inhibitor that targets the G1 phase of the cell cycle by depleting cyclin E, inducing p53 and p21, and inhibiting CDK2, thereby causing a blockade in the G1/S transition.
Web ID
– T4321
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C14H12ClN3O4S2
Citations
– 1. Lu J, Jiang H, Li D, et al. Proximity Labeling, Quantitative Proteomics, and Biochemical Studies Revealed the Molecular Mechanism for the Inhibitory Effect of Indisulam on the Proliferation of Gastric Cancer Cells. Journal of Proteome Research. 2021
2. Lu J, Li D, Jiang H, et al.The aryl sulfonamide indisulam inhibits gastric cancer cell migration by promoting the ubiquitination and degradation of the transcription factor ZEB1.Journal of Biological Chemistry.2023: 103025.
3. Hou C, Wu X, Shi R, et al.Subtle structural alteration in indisulam switches the molecular mechanisms for the inhibitory effect on the migration of gastric cancer cells.Biomedicine & Pharmacotherapy.2024, 172: 116259.
4. Liu C, Shen M, Liu Y, et al.CRISPRi/a screens in human iPSC-cardiomyocytes identify glycolytic activation as a druggable target for doxorubicin-induced cardiotoxicity.Cell Stem Cell.2024
5. Lu C, Li J, Li D, et al.RNA-binding motif protein RBM39 enhances the proliferation of gastric cancer cells by facilitating an oncogenic splicing switch in MRPL33.Acta Pharmacologica Sinica.2025: 1-14.
References
– Ozawa Y.et al.E7070, a novel sulphonamide agent with potent antitumour activity in vitro and in vivo.Eur J Cancer. 2001 Nov;37(17):2275-82.
CAS Number
– 165668-41-7
Molecular Weight
– C14H12ClN3O4S2
Compound Purity
– 0.9907
SMILES
– NS(=O)(=O)c1ccc(cc1)S(=O)(=O)Nc1cccc2c(Cl)c[nH]c12
Pathway
– Cell Cycle/Checkpoint|||Metabolism
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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