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IDO1/TDO-IN-4
$130 – $940
Products Details
Product Description
– IDO1/TDO-IN-4 is a potent IDO1/TDO dual inhibitor, with IC50 values of 3.53 μM (IDO1) and 1.15 μM (TDO). IDO1/TDO-IN-4 forms hydrogen bond with IDO1, and π−π stacking interaction with TDO. IDO1/TDO-IN-4 can be used in the research of depression, and depression-induced infectious, metabolic, and autoimmune disorders[1].
Web ID
– HY-151108
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C14H10N4
References
– [1]Yu Zhang, et al. B Discovery of 1-(Hetero)aryl-β-carboline Derivatives as IDO1/TDO Dual Inhibitors with Antidepressant Activity. J Med Chem. 2022 Aug 7.
CAS Number
– 461424-21-5
Molecular Weight
– 234.26
Compound Purity
– 99.23
SMILES
– C12=CC=CC=C1NC3=C2C=CN=C3C4=CNC=N4
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology; Neurological Disease
Solubility
– DMSO : 125 mg/mL (ultrasonic;warming;heat to 60°C)|Methanol : 16.67 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Indoleamine 2,3-Dioxygenase (IDO)
Isoform
– IDO1
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
