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Products Details
Product Description
– HPK1-IN-21 is a potent inhibitor of HPK1 kinase inhibitor (Ki=0.8 nM). HPK1-IN-21 also has orally active[1].
Web ID
– HY-144073
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C22H25ClFN5O2
References
– [1]Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1). ACS Med Chem Lett. 2021, 13(1):84-91.
CAS Number
– 2413804-83-6
Molecular Weight
– 445.92
SMILES
– CN(C(C1=C(C(C2=C(C3=C(NC[C@@]34CC[C@](C(N)=O)(C4)C)N=C2)Cl)=CC=C1N)F)=O)C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– MAP4K
Isoform
– MAP4K1/HPK1
Pathway
– MAPK/ERK Pathway
Product type
– Peptides
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
