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Product Description
– Opiorphin, an opioid peptide, is a potent enkephalin-inactivating zinc ectopeptidases in human inhibitor. Opiorphin inhibits two enkephalin-catabolizing ectoenzymes, human neutral ecto-endopeptidase, hNEP (EC 3.4.24.11) with an IC50 value of 11 μM, and human ecto-aminopeptidase, hAP-N (EC 3.4.11.2). Opiorphin displays potent analgesic activity by activating endogenous opioid-dependent transmission[1][2].
Web ID
– HY-W345510
Shipping
– Room temperature
Molecular Formula
– C29H48N12O8
References
– [1]Wisner A, et, al. Human Opiorphin, a natural antinociceptive modulator of opioid-dependent pathways. Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17979-84.|[2]Tian XZ, et, al. Effects and underlying mechanisms of human opiorphin on colonic motility and nociception in mice. Peptides. 2009 Jul;30(7):1348-54.
CAS Number
– 864084-88-8
Molecular Weight
– 692.77
SMILES
– OC[C@H](NC([C@H](CC1=CC=CC=C1)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)N)=O)=O)=O)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Neprilysin
Pathway
– Metabolic Enzyme/Protease
Product type
– Peptides
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
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