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Products Details
Product Description
– hCAIX/XII-IN-6 is an orally active carbonic anhydrase (CA) inhibitor. hCAIX/XII-IN-6 inhibits human CA isoforms hCA I, II, IV, IX, and XII with Ki values of 6697 nM, 2950 nM, 4093 nM, 4.1 nM and 7.7 nM, respectively. hCAIX/XII-IN-6 can be used for the research of rheumatoid arthritis (RA)[1].
Web ID
– HY-151472
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C26H23N3O6S4
References
– [1]Alessandro Bonardi, et al. Development of Hydrogen Sulfide-Releasing Carbonic Anhydrases IX- and XII-Selective Inhibitors with Enhanced Antihyperalgesic Action in a Rat Model of Arthritis. J Med Chem. 2022 Sep 19.
Molecular Weight
– 601.74
SMILES
– O=C(N(CC1=CC=C([N+]([O-])=O)C=C1OC)CCC2=CC=C(S(=O)(N)=O)C=C2)C3=CC=C(C4=CSSC4=S)C=C3
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Carbonic Anhydrase
Isoform
– CA â…¡;CA â…¨;CA XII
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
