Download Files:
GSK215
Price range: 203 CAD through 2,480 CAD
Products Details
Product Description
– GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader (pDC50= 8.4), designed using the FAK inhibitor VS-4718 and a binder for the VHL E3 ligase, capable of inducing rapid and prolonged FAK degradation.
Web ID
– T67843
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C50H59F3N10O6S
References
– Law RP, Nunes J, Chung CW, et al. Discovery and Characterisation of Highly Cooperative FAK-Degrading PROTACs [published online ahead of print, 2021 Aug 20]. Angew Chem Int Ed Engl. 2021;10.1002/anie.202109237.
CAS Number
– 2743427-26-9
Molecular Weight
– C50H59F3N10O6S
Compound Purity
– 0.993
SMILES
– CNC(=O)c1ccccc1Nc1cc(Nc2ccc(cc2OC)N2CCN(CC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@@H](C)c3ccc(cc3)-c3scnc3C)C(C)(C)C)CC2)ncc1C(F)(F)F
Pathway
– Tyrosine Kinase/Adaptors|||Angiogenesis|||PROTAC|||Cytoskeletal Signaling
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
Related Products
1000 in stock
1000 in stock
1000 in stock
