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GSK 690 (Hydrochloride)
$180 – $1,750
Products Details
Product Description
– GSK 690 (Hydrochloride) is a reversible inhibitor of lysine specific demethylase 1 (LSD1), with a Kd value of 9 nM and a biochemical IC50 of 37 nM.
Web ID
– HY-117226A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Molecular Formula
– C24H24ClN3O
References
– [1]Mould DP, et al. Development of (4-Cyanophenyl)glycine Derivatives as Reversible Inhibitors of Lysine Specific Demethylase 1. J Med Chem. 2017 Oct 12;60(19):7984-7999.|[2]Haydn T, et al. Concomitant epigenetic targeting of LSD1 and HDAC synergistically induces mitochondrial apoptosis in rhabdomyosarcoma cells. Cell Death Dis. 2017 Jun 15;8(6):e2879.
CAS Number
– 2436760-79-9
Molecular Weight
– 405.92
Compound Purity
– 99.16
SMILES
– N#CC1=CC=C(C2=CC(OC[C@H]3CNCC3)=CN=C2C4=CC=C(C)C=C4)C=C1.Cl
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– DMSO : 125 mg/mL (ultrasonic)
Target
– Histone Demethylase
Isoform
– KDM1/LSD1
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
