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GSK-1482160
Price range: 48 CAD through 392 CAD
Products Details
Product Description
– GSK-1482160 is a CNS-penetrant negative allosteric modulator of P2X7 receptor with oral activity. The P2X7 receptor is involved in the production of pro-inflammatory cytokines by central and peripheral immune cells, so GSK-1482160 has the potential to study inflammatory diseases. GSK-1482160 shows excellent in vitro potency (in functional and electrophysiological assays at recombinant and naive P2X7 receptors across multiple species including humans) and cross-target selectivity.
Web ID
– T61025
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C14H14ClF3N2O2
References
– Ali Z, et al. Pharmacokinetic and pharmacodynamic profiling of a P2X7 receptor allosteric modulator GSK1482160 in healthy human subjects. Br J Clin Pharmacol. 2013 Jan;75(1):197-207.
CAS Number
– 1001389-72-5
Molecular Weight
– C14H14ClF3N2O2
Compound Purity
– 0.9987
SMILES
– CN1[C@@H](CCC1=O)C(=O)NCc1cccc(c1Cl)C(F)(F)F
Pathway
– Membrane transporter/Ion channel|||Neuroscience
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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