GS-829845

$50$90

Products Details

Product Description

– GS-829845 is a major, active metabolite of Filgotinib (HY-18300). GS-829845 is a JAK1 preferential inhibitor but is approximately 10-fold less potent than the parent and with a longer half-life[1][2].

Web ID

– HY-W394903

Storage Temperature

– 4°C (Powder, sealed storage, away from moisture and light)

Shipping

– Room Temperature

Molecular Formula

– C17H19N5O2S

References

– [1]Amy Meng, et al. Exposure-response relationships for the efficacy and safety of filgotinib and its metabolite GS-829845 in subjects with rheumatoid arthritis based on phase 2 and phase 3 studies. Br J Clin Pharmacol. 2022 Jul;88(7):3211-3221.|[2]Chia-Hsiang Hsueh, et al. Evaluation of the potential drug interactions mediated through P-gp, OCT2, and MATE1/2K with filgotinib in healthy subjects. Clin Transl Sci. 2022 Feb;15(2):361-370.

CAS Number

– 1257705-09-1

Molecular Weight

– 357.43

Compound Purity

– 99.91

SMILES

– O=S1(CCN(CC1)CC2=CC=C(C3=CC=CC4=NC(N)=NN43)C=C2)=O

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– DMSO : 100 mg/mL (ultrasonic)

Target

– Drug Metabolite, JAK

Isoform

– JAK1

Pathway

– Epigenetics, JAK/STAT Signaling, Metabolic Enzyme/Protease, Protein Tyrosine Kinase/RTK, Stem Cell/Wnt

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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