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Products Details
Product Description
– GS-443902 (GS-441524 triphosphate) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 µM, 5 µM for RSV RdRp and HCV RdRp, respectively. GS-443902 is the active triphosphate metabolite of Remdesivir[1][2].
Web ID
– HY-126303
Storage Temperature
– -20°C (Powder, stored under nitrogen)
Shipping
– Blue Ice
Applications
– COVID-19-anti-virus
Molecular Formula
– C12H16N5O13P3
Citations
– Acta Pharm Sin B. 2021 Mar 22.|Cell. 2022 Nov 10;185(23):4347-4360.e17.|Chem Biol Interact. 2021 Apr 19;109480.|Current Research in Pharmacology and Drug Discovery. 2021, 100045.|Int J Mol Sci. 2022, 23(15), 8302.|Research Square Preprint. 2022 May.|Nat Commun. 2021 Oct 4;12(1):5811.
References
– [1]Siegel D, et al. Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. Med Chem. 2017 Mar 9;60(5):1648-1661.|[2]Cho A, et al. Synthesis and antiviral activity of a series of 1′-substituted 4-aza-7,9-dideazaadenosine C-nucleosides. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2705-7.|[3]Warren TK, et al. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature. 2016 Mar 17;531(7594):381-5.
CAS Number
– 1355149-45-9
Molecular Weight
– 531.20
Compound Purity
– 99.87
SMILES
– O=P(OP(O)(O)=O)(O)OP(OC[C@@H](O1)[C@@H](O)[C@@H](O)[C@]1(C#N)C2=CC=C3N2N=CN=C3N)(O)=O
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– H2O : 100 mg/mL (ultrasonic)
Target
– DNA/RNA Synthesis;Drug Metabolite;HCV;RSV;SARS-CoV
Pathway
– Anti-infection;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
