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GMB-475
Price range: 141 CAD through 3,888 CAD
Products Details
Product Description
– GMB-475 is a BCR-ABL1 tyrosine kinase degrader based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL).resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein
Web ID
– T8488
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C43H46F3N7O7S
References
– Burslem GM, et al. Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-mediated Targeted Protein Degradation. Cancer Res. 2019 Jul 16. pii: canres.1236.2019.
CAS Number
– 2490599-18-1
Molecular Weight
– C43H46F3N7O7S
Compound Purity
– 1
SMILES
– Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOc2ccc(cc2)-c2cc(Nc3ccc(OC(F)(F)F)cc3)ncn2)C(C)(C)C)cc1
Pathway
– PROTAC|||Tyrosine Kinase/Adaptors|||Angiogenesis|||Cytoskeletal Signaling
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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