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Product Description
– Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway. Gliotoxin is a mycotoxin produced by several moulds such as Aspergillus fumigatus. Gliotoxin activates PKA and increases intracellular cAMP concentration and inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis.
Web ID
– TN1694
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C13H14N2O4S2
References
– Zhang C, et al. Gliotoxin Induces Cofilin Phosphorylation to Promote Actin Cytoskeleton Dynamics and Internalization of Aspergillus fumigatus Into Type II Human Pneumocyte Cells. Front Microbiol. 2019 Jun 18;10:1345.
CAS Number
– 67-99-2
Molecular Weight
– C13H14N2O4S2
SMILES
– CN1C(=O)[C@]23CC4=CC=C[C@H](O)[C@H]4N2C(=O)[C@@]1(CO)SS3
Pathway
– Neuroscience|||Apoptosis|||Stem Cells|||Immunology/Inflammation|||Cytoskeletal Signaling|||Microbiology/Virology|||Tyrosine Kinase/Adaptors|||NF-κB
Product type
– Natural Product
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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