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Products Details
Product Description
– Gentamicin, an orally active aminoglycoside antibiotic, inhibits the growth of both gram-positive and gram-negative bacteria and to inhibit several strains of mycoplasma in tissue culture. Gentamicin inhibits DNase I with an IC50 of 0.57 mM[1][2][3][4].
Web ID
– HY-A0276A
Shipping
– Room temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C(19-21)H(39-43)N5O7
Citations
– Biomed Pharmacother. 2023 Nov 8:115856.|Curr Microbiol. 2023 May 31;80(7):230.|Food Chem. 2022 Sep 26;403:134399.|Int J Med Microbiol. 2023 Mar 28;313(2):151578.|Nat Microbiol. 2023 Mar;8(3):410-423.|ACS Appl Mater Interfaces. 2019 Oct 16;11(41):38190-38204. |Am J Physiol Cell Physiol. 2019 Aug 1;317(2):C277-C286.|Appl Microbiol Biotechnol. 2022 Apr;106(7):2689-2702.|Aquaculture. 2021, 736248.|Cell Death Dis. 2023 Jan 11;14(1):15.|Cell Transplant. Jan-Dec 2021;30:963689721997151.|Evid Based Complement Alternat Med. 2015;2015:639412.|J Ethnopharmacol. 2020 Sep 15;259:112882. |Mol Immunol. 2017 Dec;92:151-160.|Mol Med Rep. 2016 Dec;14(6):5304-5310.|Mutat Res Genet Toxicol Environ Mutagen. 2023 Apr 5,503636.|Nat Commun. 2022 Mar 2;13(1):1116.|Research Square Print. October 6th, 2022.|Toxicology. 2022 Nov 29;483:153386.
References
– [1]Xu W, et al. A rapid and sensitive method for kinetic study and activity assay of DNase I in vitro based on a GO-quenched hairpin probe. Anal Bioanal Chem. 2016 May;408(14):3801-9.|[2]Rudin A, et al. Antibacterial activity of gentamicin sulfate in tissue culture. Appl Microbiol. 1970 Dec;20(6):989-90.|[3]Kumar CG, et al. Microbial biosynthesis and applications of gentamicin: a critical appraisal. Crit Rev Biotechnol. 2008;28(3):173-212.|[4]Espersen F, et al. Effect of treatment with methicillin and gentamicin in a new experimental mouse model of foreignbody infection. Antimicrob Agents Chemother. 1994 Sep;38(9):2047-53.
CAS Number
– 1403-66-3
Molecular Weight
– N/A
SMILES
– O[C@]1(C)C(NC)[C@@H](O)[C@@H](O[C@H]2C(N)C[C@H](N)[C@@H](O[C@@H]3[C@H](N)CC[C@@H]([R])O3)[C@@H]2O)OC1.NC[*].C[C@H]([*])N.C[C@H]([*])NC.[R=].[or].[or]
Clinical Information
– Launched
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Antibiotic;Bacterial
Isoform
– Aminoglycoside
Pathway
– Anti-infection
Product type
– Reference compound
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