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Geldanamycin
Price range: 62 CAD through 317 CAD
Products Details
Product Description
– Geldanamycin, an HSP90 inhibitor (Kd: 1.2 μM), specifically disrupts glucocorticoid receptor (GR)/HSP association.
Web ID
– T6343
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C29H40N2O9
Citations
– 1. Siddiqui F A, Parkkola H, Manoharan G B, et al. Medium-Throughput Detection of Hsp90/Cdc37 Protein-Protein Interaction Inhibitors Using a Split Renilla Luciferase-Based Assay. SLAS DISCOVERY: Advancing the Science of Drug Discovery. 2020, 25(2): 195-206
2. Wu Z, Geng Y, Lu X, et al. Chaperone-mediated autophagy is involved in the execution of ferroptosis. Proceedings of the National Academy of Sciences. 2019 Feb 19;116(8):2996-3005
3. Díaz-Díaz A, Roca-Lema D, Casas-Pais A, et al. Heat Shock Protein 90 Chaperone Regulates the E3 Ubiquitin-Ligase Hakai Protein Stability. Cancers. 2020, 12(1): 215
4. Siddiqui F A, Parkkola H, Vukic V, et al. Novel Small Molecule Hsp90/Cdc37 Interface Inhibitors Indirectly Target K-Ras-Signaling. Cancers. 2021 Feb 23;13(4):927. doi: 10.3390/cancers13040927.
5. Wei Shi, Guang Xu, Xiaoyan Zhan, Yuan Gao, Zhilei Wang, Shubin Fu, Nan Qin, Xiaorong Hou, Yongqiang Ai, Chunyu Wang, Tingting He, Hongbin Liu, Yuanyuan Chen, Yan Liu, Jiabo Wang, Ming Niu, Yuming Guo, Xiaohe Xiao & Zhaofang Bai Carnosol inhibits inflammasome activation by directly targeting HSP90 to treat inflammasome-mediated diseases. Cell Death & Disease. 2020
6. Siddiqui F A, Parkkola H, Manoharan G, et al. Medium-Throughput Detection of Hsp90/Cdc37 Protein–Protein Interaction Inhibitors Using a Split Renilla Luciferase-Based Assay. SLAS Discovery. 2020, 25(2): 195-206
7. Xiong J, Wang L, Feng Y, et al.Geldanamycin confers fungicidal properties to azole by triggering the activation of succinate dehydrogenase.Life Sciences.2024: 122699.
8. Li W, Feng Y, Feng Z, et al.Pitavastatin Calcium Confers Fungicidal Properties to Fluconazole by Inhibiting Ubiquinone Biosynthesis and Generating Reactive Oxygen Species.Antioxidants.2024, 13(6): 667.
9. guo, Yang J, Liu N, et al.Polydatin-Mediated Inhibition of HSP90α Disrupts NLRP3 Complexes and Alleviates Acute Pancreatitis.Research.2024
References
– Roe SM, et al, J Med Chem, 1999, 42(2), 260-266.
CAS Number
– 30562-34-6
Molecular Weight
– C29H40N2O9
Compound Purity
– 0.9927
SMILES
– [H][C@@]1(C)CC2=C(OC)C(=O)C=C(NC(=O)C(C)=C/C=C[C@]([H])(OC)[C@]([H])(OC(N)=O)C(C)=C/[C@@]([H])(C)C(O)[C@@]([H])(C1)OC)C2=O
Pathway
– Cytoskeletal Signaling|||Metabolism|||Microbiology/Virology|||Tyrosine Kinase/Adaptors
Product type
– Natural Product
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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