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Gefitinib-based PROTAC 3
Price range: 61 CAD through 629 CAD
Products Details
Product Description
– Gefitinib-based PROTAC 3, which connects an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827 (exon 19 del) and H3255 (L858R mutation) cells, respectively[1].
Web ID
– T5437
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C47H57ClFN7O8S
References
– Burslem GM, et al. The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study. Cell Chem Biol. 201. Jan 18;25(1):67-77.e3.
CAS Number
– 2230821-27-7
Molecular Weight
– C47H57ClFN7O8S
Compound Purity
– 0.9729
SMILES
– N(C=1C2=C(C=C(OC)C(OCCCCCOCCOCCC(N[C@H](C(=O)N3[C@H](C(NCC4=CC=C(C=C4)C=5SC=NC5C)=O)C[C@@H](O)C3)[C@](C)(C)C)=O)=C2)N=CN1)C6=CC(Cl)=C(F)C=C6
Pathway
– Angiogenesis|||JAK/STAT signaling|||PROTAC|||Tyrosine Kinase/Adaptors
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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