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Galanthamine
$66 – $106
Products Details
Product Description
– Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM.
Web ID
– HY-76299
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C17H21NO3
Citations
– Antioxidants (Basel). 2022 Feb 14;11(2):385.|Asian Pac J Trop Med. 2018, 8(10):500-512.|Biochem Pharmacol. 2020 Oct;180:114139.|bioRxiv. 2023 Jun 3.|J Chromatogr A. 2023 Aug 25, 464330.|J Pharmacol Sci. 21 February 2022.|Microorganisms. 2022, 10(10), 2089.|Nat Commun. 2023 Apr 17;14(1):2182.|Research Square Preprint. June 16th, 2022.|Antioxidants (Basel). 2022, 11(7), 1228.|Free Radic Biol Med. 2019 Dec;145:20-32.
References
– [1]Melanie-Jayne R. Howes, et al. Acetylcholinesterase inhibitors of natural origin. International Journal of Research in Pharmaceutical and Biomedical Sciences 3(SI 1):67-86.|[2]Kuryatov A, et al. Roles of accessory subunits in alpha4beta2(*) nicotinic receptors. Mol Pharmacol. 2008 Jul;74(1):132-43.|[3]Kita Y, et al. Galantamine increases hippocampal insulin-like growth factor 2 expression via α7 nicotinic acetylcholine receptors in mice. Psychopharmacology (Berl). 2013 Feb;225(3):543-51.
CAS Number
– 357-70-0
Molecular Weight
– 287.35
Compound Purity
– 99.96
SMILES
– O[C@@H]1C[C@@H]2OC3=C4C(CN(C)CC[C@]42C=C1)=CC=C3OC
Clinical Information
– Launched
Research Area
– Neurological Disease
Solubility
– 1M HCl : 50 mg/mL (ultrasonic;adjust pH to 1 with HCl)|DMSO : ≥ 59 mg/mL
Target
– Apoptosis;Cholinesterase (ChE)
Isoform
– AChE
Pathway
– Apoptosis;Neuronal Signaling
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
