Products Details

Product Description

– Fluticasone propionate-d5 is deuterium labeled Fluticasone (propionate). Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity[1][2].

Web ID

– HY-B0154S1

Shipping

– Room temperature

Applications

– Metabolism-sugar/lipid metabolism

Molecular Formula

– C25H26D5F3O5S

References

– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Bryson HM, et al. Intranasal fluticasone propionate. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in allergic rhinitis. Drugs. 1992;43(5):760-775.|[3]Johnson M. The anti-inflammatory profile of fluticasone propionate. Allergy. 1995;50(23 Suppl):11-14.|[4]Singanayagam A, et al. Effect of fluticasone propionate on virus-induced airways inflammation and anti-viral immune responses in mice. Lancet. 2015 Feb 26;385 Suppl 1:S88.

CAS Number

– 1093258-28-6

Molecular Weight

– 505.60

SMILES

– [2H]C([2H])([2H])C([2H])([2H])C(O[C@]1([C@@]2([C@@]([C@@]3([H])[C@]([C@H](C2)O)([C@@]4(C([C@H](C3)F)=CC(C=C4)=O)C)F)([H])C[C@H]1C)C)C(SCF)=O)=O

Clinical Information

– No Development Reported

Research Area

– Infection; Endocrinology; Inflammation/Immunology

Solubility

– 10 mM in DMSO

Target

– Endogenous Metabolite;Enterovirus;Glucocorticoid Receptor;Isotope-Labeled Compounds

Pathway

– Anti-infection;Immunology/Inflammation;Metabolic Enzyme/Protease;Others;Vitamin D Related/Nuclear Receptor

Product type

– Isotope-Labeled Compounds

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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