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Products Details
Product Description
– Fluticasone furoate-d3 is deuterium labeled Fluticasone furoate. Fluticasone furoate is a topical, intranasal, enhanced-affinity synthetic trifluorinated corticosteroid with a Kd of 0.3 nM. Fluticasone furoate has potent anti-inflamatory and anti-asthmatic activity, and low systemic exposure. Fluticasone furoate has the potential for allergic rhinitis treatment[1][2].
Web ID
– HY-15234S
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C27H26D3F3O6S
References
– [1]Alizadeh Z, et al. Asthma phenotypes and T-bet protein expression in cells treated with Fluticasone Furoate/Vilanterol. Pulm Pharmacol Ther. 2020 Feb;60:101886.|[2]Giavina-Bianchi P, et al. Fluticasone furoate nasal spray in the treatment of allergic rhinitis. Ther Clin Risk Manag. 2008 Apr;4(2):465-72.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
Molecular Weight
– 541.59
SMILES
– O=C(C1=C([2H])C([2H])=C([2H])O1)O[C@]2([C@@]3([C@@]([C@@]4([H])[C@]([C@H](C3)O)([C@@]5(C([C@H](C4)F)=CC(C=C5)=O)C)F)([H])C[C@H]2C)C)C(SCF)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Glucocorticoid Receptor;Isotope-Labeled Compounds
Pathway
– Immunology/Inflammation;Others;Vitamin D Related/Nuclear Receptor
Product type
– Isotope-Labeled Compounds
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