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FC 11
1,000 CAD
Only 1000 item(s) left in stock.
Products Details
Product Description
– FC 11 is a highly potent focal adhesion Ki nase (FAK) PROTAC®Degrader (DC50 values are 40 to 370 pM depending on cell line), which is composed of the FAK inhibitor PF 562217 joined by a linker to the cereblon-binding ligand Pomalidomide. The effects of FC 11 are reversible upon compound wash out. FC 11 also degrades autophosphorylated FAK (pFAKtyr397), displaying near complete degradation after 3 hours at 100 nM in TM3 cells.
Web ID
– T41164
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C41H42F3N13O9S
References
– Gao et al (2019) Design, synthesis, and evaluation of highly potent FAK-targeting PROTACs. ACS.Med.Chem.Lett. 11 1855 PMID: 33062164
CAS Number
– 2271035-37-9
Molecular Weight
– C41H42F3N13O9S
SMILES
– O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCOCCOCCN4C=C(C(NC5=CC=C(NC=6N=C(NCC7=C(N(S(C)(=O)=O)C)N=CC=C7)C(C(F)(F)F)=CN6)C=C5)=O)N=N4
Pathway
– PROTAC
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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