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Exendin-4 (acetate)
$79 – $396
Products Details
Product Description
– Exendin-4 acetate (Exenatide acetate), a 39 amino acid peptide, is a long-acting glucagon-like peptide-1 receptor agonist with an IC50 of 3.22 nM.
Web ID
– HY-13443A
Storage Temperature
– -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Shipping
– Blue Ice
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C186H286N50O62S
Citations
– Biomaterials. 2021 Aug;275:120944.|Acta Biochim Biophys Sin (Shanghai). 2017 Jul 1;49(7):573-580.|Am J Physiol Endocrinol Metab. 2020 Dec 1;319(6):E1019-E1030.|Annals of the Romanian Society for Cell Biology. 2021 Mar 15.|Biochim Biophys Acta Mol Cell Res. 2022 May 27;1869(9):119300.|Biomedicines. 2020 Nov 9;8(11):485.|bioRxiv. 2020 Jul.|BMC Biol. 2021 Mar 3;19(1):40.|Br J Pharmacol. 2020 Aug;177(15):3389-3402. |Chem Biol Interact. 2019 May 1;304:186-193.|Drug Deliv. 2022 Dec;29(1):548-560.|Exp Cell Res. 2023 Jan 7;113469.|Front Behav Neurosci. 05 January 2022.|Front Pharmacol. 2019 Oct 25;10:1230.|Front Pharmacol. 2021 Jul 19;12:694476.|Gerontology. 2023 Mar 7;1-12.|Gut. 2022 Jun 13;gutjnl-2021-326541.|Int Immunopharmacol. 2021 Jan;90:107192.|Int Immunopharmacol. 2023 May 19;120:110339.|Int J Biol Sci. 2022; 18(4): 1328-1346.|J Biol Chem. 2018 Nov 23;293(47):18086-18098. |J Cell Physiol. 2021 May;236(5):3641-3659.|J Diabetes Res. 2019 Dec 9;2019:8905917.|J Funct Foods. 2023 Aug, 107, 105706.|J Invest Dermatol. 2021 Oct 20;S0022-202X(21)02369-1.|J Neuroinflammation. 2019 Nov 28;16(1):242.|Mol Metab. 2023 Sep 26, 101811.|Neural Regen Res. 2022.|Neurogastroenterol Motil. 2019 Feb;31(2):e13482.|Sci Rep. 2017 Jun 28;7(1):4351.|SSRN. 2019 Jun 27.|Structure. 2022 Feb 2;S0969-2126(22)00006-5.
References
– [1]Doyle ME, et al. The importance of the nine-amino acid C-terminal sequence of exendin-4 for binding to the GLP-1 receptor and for biological activity. Regul Pept. 2003 Jul 15;114(2-3):153-8.|[2]Wei R, et al. Exenatide exerts direct protective effects on endothelial cells through the AMPK/Akt/eNOS pathway in a GLP-1 receptor-dependent manner. Am J Physiol Endocrinol Metab. 2016 Jun 1;310(11):E947-57.|[3]Fidan-YaylalI G, et al. Antidiabetic exendin-4 activates apoptotic pathway and inhibits growth of breast cancer cells. Tumour Biol. 2016 Feb;37(2):2647-53.|[4]Ding X, et al. Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/obmice. Hepatology. 2006 Jan;43(1):173-81.|[5]Nachnani JS, et al. Biochemical and histological effects of exendin-4 (exenatide) on the rat pancreas. Diabetologia. 2010 Jan;53(1):153-9.|[6]Sélley E, et al. Exenatide induces aortic vasodilation increasing hydrogen sulphide, carbon monoxide and nitric oxide production. Cardiovasc Diabetol. 2014 Apr 2;13:69.
CAS Number
– 914454-01-6
Molecular Weight
– 4246.62
Compound Purity
– 99.67
SMILES
– CC(O)=O.O=C(NCC(N[C@@H](CCC(O)=O)C(NCC(N[C@@H]([C@H](O)C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCSC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(NCC(NCC(N5[C@@H](CCC5)C(N[C@@H](CO)C(N[C@@H](CO)C(NCC(N[C@@H](C)C(N6[C@@H](CCC6)C(N7[C@@H](CCC7)C(N8[C@@H](CCC8)C(N[C@@H](CO)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC9=CNC=N9)N
Clinical Information
– Launched
Research Area
– Metabolic Disease
Solubility
– DMSO : ≥ 66.66 mg/mL|H2O : 25 mg/mL (ultrasonic)
Target
– GCGR
Pathway
– GPCR/G Protein
Product type
– Peptides
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
