ESI-05

$66$605

Products Details

Product Description

– ESI-05 is a specific exchange proteins directly activated by cAMP 2 (EPAC2) inhibitor. ESI-05 inhibits cAMP-mediated EPAC2 GEF activity with an IC50 of 0.43 μM. ESI-05 can be used for the research of diabetes, insulin secretion and neurological disorders[1][2].

Web ID

– HY-117656

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Molecular Formula

– C16H18O2S

References

– [1]Tsalkova T, et al. Isoform-specific antagonists of exchange proteins directly activated by cAMP. Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18613-8.|[2]Yan Zhuang, et al. Inhibition of EPAC2 Attenuates Intracerebral Hemorrhage-Induced Secondary Brain Injury via the p38/BIM/Caspase-3 Pathway. J Mol Neurosci. 2019 Mar;67(3):353-363.

CAS Number

– 5184-64-5

Molecular Weight

– 274.38

Compound Purity

– 99.94

SMILES

– O=S(C1=C(C)C=C(C)C=C1C)(C2=CC=C(C)C=C2)=O

Clinical Information

– No Development Reported

Research Area

– Metabolic Disease; Neurological Disease

Solubility

– DMSO : 50 mg/mL (ultrasonic)

Target

– Acyltransferase

Pathway

– Metabolic Enzyme/Protease

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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