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Products Details
Product Description
– erythro-Austrobailignan-6 is an orally active anti-cancer agent. erythro-Austrobailignan-6 inhibits DNA topoisomerase I and II activity. erythro-Austrobailignan-6 induces cell apoptosis and increases phosphorylation of p38 and JNK[1][2].
Web ID
– HY-N11536
Shipping
– Room temperature
Molecular Formula
– C20H24O4
References
– [1]Han JH, et al. Erythro-austrobailignan-6 down-regulates HER2/EGFR/integrinβ3 expression via p38 activation in breast cancer. Phytomedicine. 2017 Jan 15;24:24-30. |[2]Lee YK, et al. Inhibition of DNA topoisomerases I and II and cytotoxicity by lignans from Saururus chinensis. Arch Pharm Res. 2009 Oct;32(10):1409-15.
CAS Number
– 114127-24-1
Molecular Weight
– 328.40
SMILES
– COC(C=C1C[C@@H](C)[C@@H](C)CC2=CC=C(OCO3)C3=C2)=C(C=C1)O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Topoisomerase
Pathway
– Apoptosis;Cell Cycle/DNA Damage
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
