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Entrectinib
Price range: 56 CAD through 1,165 CAD
Products Details
Product Description
– Entrectinib (RXDX-101) is a Trk, ROS1, and ALK inhibitor that inhibits TrkA, TrkB, TrkC, ROS1, and ALK (IC50=1/3/5/12/7 nM) with oral activity and blood-brain-barrier penetration. Entrectinib exhibits both antitumor and CNS activity.
Web ID
– T3678
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C31H34F2N6O2
Citations
– 1. Shi S, Ma B, Sun F, et al. Zafirlukast inhibits the growth of lung adenocarcinoma via inhibiting TMEM16A channel activity. Journal of Biological Chemistry. 2022, 298(3).
2. Qin Q, Fu Q, Wang X, et al.Design, synthesis and biological evaluation of novel indolin-2-one derivatives as potent second-generation TRKs inhibitors.European Journal of Medicinal Chemistry.2023: 115291.
3. Jin X, Liu D, Zhou X, et al.Entrectinib inhibits NLRP3 inflammasome and inflammatory diseases by directly targeting NEK7.Cell Reports Medicine.2023, 4(12).
4. Ding X, Li X, Fang R, et al.Targeting PYK2, entrectinib allays anterior subcapsular cataracts in mice by regulating TGFβ2 signaling pathway.Molecular Medicine.2024, 30(1): 1-15.
References
– Rolfo C, et al. Expert Opin Investig Drugs. 2015, 24(11), 1493-1500.
CAS Number
– 1108743-60-7
Molecular Weight
– C31H34F2N6O2
Compound Purity
– 0.9961
SMILES
– N(C(=O)C1=C(NC2CCOCC2)C=C(C=C1)N3CCN(C)CC3)C=4C=5C(NN4)=CC=C(CC6=CC(F)=CC(F)=C6)C5
Pathway
– Immunology/Inflammation|||Angiogenesis|||Autophagy|||Tyrosine Kinase/Adaptors
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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