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Entinostat
Price range: 80 CAD through 309 CAD
Products Details
Product Description
– Entinostat (MS-275) is an HDAC class I selective inhibitor of HDAC1, HDAC2 and HDAC3 (IC50=243/453/248 nM) with oral activity. Entinostat has antitumor activity.
Web ID
– T6233
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C21H20N4O3
Citations
– 1. Moreno-Yruela C, Zhang D, Wei W, et al. Class I Histone Deacetylases (HDAC1‒3) are Histone Lysine Delactylases. Science advances. 2022, 8(3): eabi6696.
2. Wellinger L C, Hogg S J, Newman D M, et al. BET Inhibition Enhances TNF Mediated Anti-Tumor Immunity. Cancer Immunology Research. 2022, 10(1): 87-107.
3. Wellinger L C, Hogg S J, Newman D M, et al. Bet inhibition enhances TNF-mediated antitumor immunity. Cancer Immunology Research. 2022, 10(1): 87-107
4. Zierfuss B, Weinhofer I, Buda A, et al. Targeting foam cell formation in inflammatory brain diseases by the histone modifier MS‐275. Annals of Clinical and Translational Neurology. 2020, 7(11): 2161-2177
5. Zhang L, Shi J, Du D, et al. Ketogenesis acts as an endogenous protective programme to restrain inflammatory macrophage activation during acute pancreatitis. eBioMedicine. 2022, 78: 103959.
6. Jiang X C, Tu F H, Wei L Y, et al. Discovery of a Novel G-Quadruplex and Histone Deacetylase (HDAC) Dual-Targeting Agent for the Treatment of Triple-Negative Breast Cancer. Journal of Medicinal Chemistry. 2022
7. Lagosz K B, Bysiek A, Macina J M, et al. HDAC3 Regulates Gingival Fibroblast Inflammatory Responses in Periodontitis. Journal of Dental Research. 2019: 0022034519885088
8. Wang C, Huang M, Lin Y, et al.ENO2-derived phosphoenolpyruvate functions as an endogenous inhibitor of HDAC1 and confers resistance to antiangiogenic therapy.Nature Metabolism.2023: 1-22.
9. Villoria-González A, Zierfuss B, Parzer P, et al.Efficacy of HDAC Inhibitors in Driving Peroxisomal β-Oxidation and Immune Responses in Human Macrophages: Implications for Neuroinflammatory Disorders.Biomolecules.2023, 13(12): 1696.
10. Bian R, Shang Y, Xu N, et al.HDAC inhibitor enhances ferroptosis susceptibility of AML cells by stimulating iron metabolism.Cellular Signalling.2025: 111583.
References
– Beckers T, et al. Distinct pharmacological properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group. Int J Cancer. 2007 Sep 1;121(5):1138-48.
CAS Number
– 209783-80-2
Molecular Weight
– C21H20N4O3
Compound Purity
– 0.9974
SMILES
– Nc1ccccc1NC(=O)c1ccc(CNC(=O)OCc2cccnc2)cc1
Pathway
– DNA Damage/DNA Repair|||Apoptosis|||Chromatin/Epigenetic|||Autophagy
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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