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Elamipretide
Price range: 77 CAD through 1,514 CAD
Products Details
Product Description
– Elamipretide (MTP-131) is a mitochondria-targeted antioxidant tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) that reduces toxic reactive oxygen species (ROS) production and stabilizes cardiolipin, with blood-brain-barrier permeability. It is a potential therapeutic agent in the rare disease of Barnes syndrome.
Web ID
– TP1095
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C32H49N9O5
Citations
– 1. Suo M, Qi Y, Liu L, et al. SS31 Alleviates Pressure Overload-Induced Heart Failure Caused by Sirt3-Mediated Mitochondrial Fusion. Frontiers in Cardiovascular Medicine. 2022.9
2. Yao S, Wu D, Hu X, et al.Platelet Membrane-Coated Bio-Nanoparticles of Indocyanine Green/Elamipretide for NIR Diagnosis and Antioxidant Therapy in Acute Kidney Injury.Acta Biomaterialia.2023
3. Hao Y, Fan Y, Feng J, et al.ALCAT1-mediated abnormal cardiolipin remodelling promotes mitochondrial injury in podocytes in diabetic kidney disease.Cell Communication and Signaling.2024, 22(1): 1-20.
4. Ji Y, Ma Y, Ma Y, et al.SS-31 inhibits mtDNA–cGAS–STING signaling to improve POCD by activating mitophagy in aged mice.Inflammation Research.2024: 1-14.
5. Bulbul O, Mammadov R, Suleyman B, et al.Effect of elamipretide and methylprednisolone treatment on optic nerve, retina and brain damage in a methanol poisoning model: biochemical and histopathological evaluation.Cutaneous and Ocular Toxicology.2024: 1-13.
6. Luo P, Gu Q, Wang J, et al.SS31 alleviates LPS-induced acute lung injury by inhibiting inflammatory responses through the S100A8/NLRP3/GSDMD signaling pathway.European Journal of Medical Research.2024, 29(1): 1-11.
7. Li Z, Wang H, Liu N, et al.Renal Lipid Alterations From Diabetes to Early‐Stage Diabetic Kidney Disease and Mitophagy: Focus on Cardiolipin.Journal of Cellular and Molecular Medicine.2025, 29(3): e70419.
References
– Petcherski A, et al. Elamipretide Promotes Mitophagosome Formation and Prevents Its Reduction Induced by Nutrient Excess in INS1 β-cells. J Mol Biol. 2018 Dec 7;430(24):4823-4833.
CAS Number
– 736992-21-5
Molecular Weight
– C32H49N9O5
Compound Purity
– 0.9985
SMILES
– [C@H](CC1=C(C)C=C(O)C=C1C)(C(N[C@H](C(N[C@@H](CC2=CC=CC=C2)C(N)=O)=O)CCCCN)=O)NC([C@@H](CCCNC(=N)N)N)=O
Pathway
– Others
Product type
– Peptide
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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