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Elacridar (hydrochloride)
$64 – $581
Products Details
Product Description
– Elacridar hydrochloride (GF120918A) is an orally active P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) inhibitor. Elacridar hydrochloride can be used to examine the influence of efflux transporters on agent distribution to brain and it can be used for the research of cancer[1][2].
Web ID
– HY-50880
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C34H34ClN3O5
Citations
– Crit Rev Anal Chem. 2021 Mar 10;1-15.|Food Chem Toxicol. 2021, 112381.|J Mater Chem B. 2018 Dec 7;6(45):7521-7529. |Mol Psychiatry. 2023 Oct 16.|Antiviral Res. 2021 Jun 28;105124.|Biomed Pharmacother. 2020 Sep;129:110506.|Biomed Res Int. 2020 Nov 29;2020:8878158.|Cell Death Dis. 2021 Jul 27;12(8):742.|Cell Death Dis. 2019 May 24;10(6):400. |Cell Rep. 2020 Jun 23;31(12):107782.|Clin Cancer Res. 2018 Jan 15;24(2):383-394.|EJNMMI Res. 2015 Mar 17;5:11. |Eur J Med Chem. 2023 Aug 17;260:115721.|Hong Kong Polytechnic University. Department of Applied Biology and Chemical Technology. 2022 Oct.|Int J Mol Sci. 2019 Mar 5;20(5). pii: E1125. |J Agric Food Chem. 2019 Feb 27;67(8):2350-2360.|J Agric Food Chem. 2022 Feb 3.|J Biol Chem. 2022 Aug 6;102353.|J Drug Target. 2016;24(5):441-9.|Molecules. 2019 Apr 27;24(9):1661. |Sci Adv. 2023 Oct 20;9(42):eabp9530.|Sci Rep. 2021 Jul 22;11(1):14948.
References
– [1]Sato H, et al. Elacridar enhances the cytotoxic effects of sunitinib and prevents multidrug resistance in renal carcinoma cells. Eur J Pharmacol. 2015 Jan 5;746:258-66.|[2]Sane R, et al. Brain distribution and bioavailability of elacridar after different routes of administration in the mouse. Drug Metab Dispos. 2012 Aug;40(8):1612-9.
CAS Number
– 143851-98-3
Molecular Weight
– 600.10
Compound Purity
– 99.93
SMILES
– O=C1C2=CC=CC(C(NC(C=C3)=CC=C3CCN4CC(C=C(C(OC)=C5)OC)=C5CC4)=O)=C2NC6=C1C=CC=C6OC.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 62.5 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– BCRP;P-glycoprotein
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
