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EGFR/ErbB-2/ErbB-4 inhibitor-2
$166 – $2,500
Products Details
Product Description
– EGFR/ErbB-2/ErbB-4 inhibitor-2 (Compound 5) is a EGFR and ErbB inhibitor with IC50s of 0.017 μM, 0.08 μM, 1.91 μM[1].
Web ID
– HY-112420
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C23H21N3O3
References
– [1]Perry S Brignola, et al. Comparison of the biochemical and kinetic properties of the type 1 receptor tyrosine kinase intracellular domains. Demonstration of differential sensitivity to kinase inhibitors. J Biol Chem. 2002 Jan 11;277(2):1576-85.
CAS Number
– 179248-61-4
Molecular Weight
– 387.43
Compound Purity
– 99.69
SMILES
– COC1=CC2=NC=NC(NC3=CC=C(OCC4=CC=CC=C4)C=C3)=C2C=C1OC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 33.33 mg/mL (ultrasonic)
Target
– EGFR
Isoform
– EGFR/ErbB1/HER1;ErbB2/HER2;ErbB4/HER4
Pathway
– JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
