Download Files:
Products Details
Product Description
– EGFR/CSC-IN-1 is a potential EGFR (IC50 10.52 nM) and cancer stem cell (CSC) dual inhibitor for triple-negative breast cancer research.
Web ID
– HY-132883
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C54H54Cl2FN7O7S2
References
– [1]Wang Y, et al. Conjugates Derived from Lapatinib Derivatives with Cancer Cell Stemness Inhibitors Effectively Reversed Drug Resistance in Triple-Negative Breast Cancer. J Med Chem. 2021 Sep 9;64(17):12877-12892.
CAS Number
– 2820447-02-5
Molecular Weight
– 1067.08
SMILES
– CS(CCN(CC1=CC=C(C2=CC3=C(N=CN=C3NC4=CC=C(OCC5=CC(F)=CC=C5)C(Cl)=C4)C=C2)O1)C(CCC(OCCN6CCN(CC6)CCCN7C8=C(SC9=C7C=C(C=C9)Cl)C=CC=C8)=O)=O)(=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– EGFR
Isoform
– EGFR/ErbB1/HER1
Pathway
– JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
