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Product Description
– Egaptivon pegol (ARC1779) is an aptamer, which blocks binding of the von Willebrand Factor (VWF) to platelet GPIb receptors. Egaptivon pegol has anti-thrombotic efficacy.
Web ID
– HY-147079
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C413H546N144O275P40S (C2H4O)n
References
– [1]Avdonin PP, Trufanov SK, Rybakova EY, Tsitrina AA, Goncharov NV, Avdonin PV. The Use of Fluorescently Labeled ARC1779 Aptamer for Assessing the Effect of H2O2 on von Willebrand Factor Exocytosis. Biochemistry (Mosc). 2021;86(2):123-131. |[2]Jilma-Stohlawetz P, Gorczyca ME, Jilma B, Siller-Matula J, Gilbert JC, Knöbl P. Inhibition of von Willebrand factor by ARC1779 in patients with acute thrombotic thrombocytopenic purpura. Thromb Haemost. 2011;105(3):545-552. |[3]Spiel AO, Mayr FB, Ladani N, et al. The aptamer ARC1779 is a potent and specific inhibitor of von Willebrand Factor mediated ex vivo platelet function in acute myocardial infarction. Platelets. 2009;20(5):334-340.
CAS Number
– 934868-74-3
Molecular Weight
– N/A
SMILES
– [Egaptivon pegol]
Clinical Information
– Phase 2
Research Area
– Cardiovascular Disease
Solubility
– H2O : 100 mg/mL (ultrasonic)
Target
– Integrin
Pathway
– Cytoskeleton
Product type
– Oligonucleotides
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
