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Eflornithine (hydrochloride hydrate)
$50 – $150
Products Details
Product Description
– Eflornithine hydrochloride hydrate (DFMO hydrochloride hydrate) is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine hydrochloride hydrate is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women[1].
Web ID
– HY-B0744B
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C6H15ClF2N2O3
Citations
– Front Oncol. 2021 Mar 11;11:636373.|Sci Adv. 2023 May 19;9(20):eade0718.|Cancer Nanotechnol. 2023 May 9.|Commun Biol. 2019 May 8;2:171.|Food Biosci. 2023 Oct, 55, 102970.|JACC Basic Transl Sci. 2022 Aug 3;7(8):820-840.|Oncotargets Ther. 2020 Nov 17;13:11697-11709.|RSC Adv. 2019, 9, 11026-11037.
References
– [1]Burri C, et al. Eflornithine for the treatment of human African trypanosomiasis. Parasitol Res. 2003 Jun;90 Supp 1:S49-52.|[2]Balfour JA, et al. Topical eflornithine. Am J Clin Dermatol. 2001;2(3):197-201; discussion 202.|[3]Kumar A, et al. A method to improve the efficacy of topical eflornithine hydrochloride cream. Drug Deliv. 2016 Jun;23(5):1495-501.|[4]Lipke DW, et al. Eflornithine alters changes in vascular responsiveness associated with coarctation hypertension. Clin Exp Hypertens. 1997 Apr;19(3):297-312.
CAS Number
– 96020-91-6
Molecular Weight
– 236.64
Compound Purity
– 98.0
SMILES
– NC(CCCN)(C(F)F)C(O)=O.[H]Cl.O
Clinical Information
– Launched
Research Area
– Cancer
Solubility
– H2O : 83.33 mg/mL (ultrasonic)
Target
– Parasite
Isoform
– Trypanosoma
Pathway
– Anti-infection
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
