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(E/Z)-Teriflunomide
$32 – $90
Products Details
Product Description
– (E/Z)-Teriflunomide ((E/Z)-A77 1726) is the active metabolite of
Leflunomide (HY-B0083). Leflunomide is an immunomodulatory agent that may exert effects by inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH). Leflunomide can be used for the research of rheumatoid arthritis (RA)[1].
Web ID
– HY-110159
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C12H9F3N2O2
References
– [1]R I Fox, et al. Mechanism of action for leflunomide in rheumatoid arthritis. Clin Immunol. 1999 Dec;93(3):198-208.
CAS Number
– 108605-62-5
Molecular Weight
– 270.21
Compound Purity
– 99.86
SMILES
– C/C(O)=C(C#N)/C(NC1=CC=C(C(F)(F)F)C=C1)=O
Clinical Information
– Launched
Research Area
– Infection; Inflammation/Immunology
Solubility
– DMSO : 50 mg/mL (ultrasonic)
Target
– Dihydroorotate Dehydrogenase
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
