Download Files:
(E)-SIS3
Price range: 58 CAD through 2,480 CAD
Products Details
Product Description
– (E)-SIS3 (SIS3), a selective Smad3 inhibitor, can attenuate TGF-β1-dependent Smad3 phosphorylation and DNA binding. It has no effect on p38 MAPK, Smad2, ERK or PI3K signaling. It also inhibits TGF-β1-induced myofibroblast differentiation of dermal fibroblasts and inhibits TGF-β2-induced endothelial cell differentiation in iPSCs.
Web ID
– T3636
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C28H27N3O3·HCl
Citations
– 1. Xu J, Ma L, Wang D, et al. Uncarboxylated osteocalcin promotes proliferation and metastasis of MDA-MB-231 cells through TGF-β/SMAD3 signaling pathway. BMC Molecular and Cell Biology. 2022, 23(1): 1-17
2. Yao H, Qian J, Bian X, et al.miR-27b-3p reduces muscle fibrosis during chronic skeletal muscle injury by targeting TGF-βR1/Smad pathway.Journal of Orthopaedic Surgery and Research.2024, 19(1): 329.
3. The TRPV1-PKM2-SREBP1 axis maintains microglial lipid homeostasis in Alzheimer’s disease[J]. Cell Death & Disease, 2025, 16(1): 14.
References
– Jinnin M, et al. Mol Pharmacol. 2006, 69(2):597-607.
CAS Number
– 521984-48-5
Molecular Weight
– C28H27N3O3·HCl
Compound Purity
– 0.9883
SMILES
– Cl.COc1cc2CCN(Cc2cc1OC)C(=O)C=Cc1c(-c2ccccc2)n(C)c2ncccc12
Target
– CDK
Pathway
– Stem Cells
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
Related Products
1000 in stock
1000 in stock
