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E 2012
$100 – $1,100
Products Details
Product Description
– E 2012 is a potent gamma (γ) secretase modulator without affecting Notch processing. E 2012 inhibits 3β-hydroxysterol Δ24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at Alzheimer’s disease by reduction of amyloid β-42, and induces cataract following repeated doses in the rat[1].
Web ID
– HY-10016
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C25H26FN3O2
References
– [1]Nakano-Ito K, et al. E2012-induced cataract and its predictive biomarkers. Toxicol Sci. 2014 Jan;137(1):249-58.|[2]Portelius E, Van Broeck B, Andreasson U, Gustavsson MK, Mercken M, Zetterberg H, Borghys H, Blennow K.Acute effect on the Aβ isoform pattern in CSF in response to γ-secretase modulator and inhibitor treatment in dogs.J Alzheimers Dis. 2010;21(3):1005-12.
CAS Number
– 870843-42-8
Molecular Weight
– 419.49
Compound Purity
– 97.08
SMILES
– O=C(N([C@H](C1=CC=C(C=C1)F)C)CCC/2)C2=CC3=CC=C(N4C=NC(C)=C4)C(OC)=C3
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : ≥ 50 mg/mL
Target
– γ-secretase
Pathway
– Neuronal Signaling;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
